It's a science fiction manga, centered around a man named Killy who is searching for "Net Terminal Genes" and is armed with a small but ridiculously powerful gun. It makes the Noisy Cricket look like a squirt gun. The whole thing is set in gargantuan (an understatement) urban environment with cyborgs and various transhuman tribes all over the place. The first volume is pretty slow, but it picks up after volume two. If nothing else, the art is amazing. You might have heard of Tsutomu Nihei from the Halo graphic novel or Wolverine: Snikt!

 

Well, I read and enjoyed Blame.

Killy is probably one of the coolest cyborgs in fiction.